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DURECT Corporation Presenting at the 4th Annual Smith Barney Citigroup Specialty Pharmaceuticals Conference


CUPERTINO, Calif., Feb. 24 /PRNewswire-FirstCall/ -- DURECT Corporation (Nasdaq: DRRX) announced today that it will present at the Smith Barney Citigroup Specialty Pharmaceuticals Conference. The conference is taking place February 24-25th at The Marriott East Side Hotel in New York City, New York. Dr. James E. Brown, President and Chief Executive Officer will be presenting at the conference on Wednesday, February 25th at 8:00 a.m. Eastern Time.

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There will be a live webcast of the presentation from the Conference. The webcast will be available on DURECT's website under the Event Calendar section of "Investor Relations." The presentation will also be available for replay on DURECT's website for a period of up to 30 days after the conference.

About DURECT Corporation

DURECT Corporation (www.durect.com) is pioneering the development and commercialization of pharmaceutical systems for the treatment of chronic debilitating diseases and enabling biotechnology-based pharmaceutical products. DURECT's goal is to deliver the right drug to the right site in the right amount at the right time. DURECT's lead product in development is CHRONOGESIC, a 3-month product for the treatment of chronic pain. DURECT also owns three proprietary drug delivery platform technologies, including the SABER Delivery System (a patented and versatile depot injectable useful for protein and small molecule delivery), the MICRODUR(TM) Biodegradable Microparticulates (microspheres injectable system) and the DURIN(TM) Biodegradable Implant (drug-loaded implant system) upon which DURECT is developing a pipeline of other products.

NOTE: CHRONOGESIC(R), SABER(TM), MICRODUR(TM) and DURIN(TM) are trademarks of DURECT Corporation.

The statements in this press release regarding DURECT's products in development and product development plans are forward-looking statements involving risks and uncertainties that can cause actual results to differ materially from those in such forward-looking statements. Potential risks and uncertainties include, but are not limited to, DURECT's ability to complete the design, development, and manufacturing process development of its products, manufacture and commercialize its products, obtain product and manufacturing approvals from regulatory agencies, manage its growth and expenses, manage relationships with third parties, finance its activities and operations, as well as marketplace acceptance of DURECT's products. Further information regarding these and other risks is included in DURECT's Annual Report on Form 10-K for the fiscal year ended December 31, 2002 filed with the SEC on March 14, 2003, DURECT's Quarterly Report on Form 10-Q for the quarter ended September 30, 2003 filed with the SEC on November 13, 2003 and other periodic reports filed with the SEC under the heading "Factors that may affect future results."

SOURCE DURECT Corporation

CONTACT: Schond L. Greenway, Investor Relations and Strategic Planning
of DURECT Corporation, +1-408-777-1417/
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