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DURECT Corporation Invites You to Join Its Fourth Quarter and Year-End 2005 Conference Call on the Web

CUPERTINO, Calif., Jan. 23 /PRNewswire-FirstCall/ -- In conjunction with DURECT Corporation's (Nasdaq: DRRX) fourth quarter and year-end 2005 financial results press release, you are invited to listen to its conference call that will be broadcast live over the Internet on Wednesday, February 8th, 2006 at 4:30 p.m. EST.

(Logo: ) What: DURECT Corporation's Fourth Quarter and Year-End 2005 Earnings Conference Call
When: Wednesday, February 8th, 2006, 4:30 p.m. EST (1:30 p.m. PST) Where: and click "Investor Relations"
Live over the Internet -- Simply log on to the Web at the address listed above.

If you are unable to participate during the live webcast, the call will be archived on DURECT's website under Audio Archive in the "Investor Relations" section.

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused on the development of pharmaceutical systems based on its proprietary drug delivery platform technologies. The company is developing pharmaceutical systems to deliver the right drug to the right place in the right amount at the right time to treat chronic and episodic diseases and conditions.

DURECT Corporation 01/23/2006

Schond L. Greenway, Vice President, Investor Relations and Strategic Planning of DURECT Corporation, +1-408-777-1417
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