DURECT is committed to transforming the treatment of acute organ injury and chronic liver diseases by advancing novel and lifesaving therapies based on its endogenous epigenetic regulator program. The company’s lead candidate, DUR-928, is the first endogenous epigenetic regulator clinically tested for difficult-to-treat diseases. DUR-928 has demonstrated the ability to regulate the expression of genes involved in lipid metabolism, inflammatory responses and cell survival. 
DUR-928 has demonstrated positive efficacy and safety profiles as a potential treatment for patients with alcoholic hepatitis (AH), a life-threatening acute alcoholic liver disease with no approved drugs and a 28-day overall mortality rate of 26%. DUR-928 has the potential to become the first drug indicated for the treatment of AH patients. DUR-928 is also being investigated in patients with nonalcoholic steatohepatitis (NASH) and in severely ill COVID-19 patients with acute liver or kidney injury. 
In addition, DURECT is leveraging its proprietary drug delivery technologies to develop treatments for postoperative pain and attention-deficit hyperactivity disorder (ADHD). 

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