DURECT is a biopharmaceutical company actively developing new therapeutics based on its Epigenetic Regulator Program and proprietary drug delivery platforms. DUR-928, a new chemical entity in Phase 1 development, is the lead candidate in DURECT’s Epigenetic Regulator Program. An endogenous, orally bioavailable small molecule, DUR-928 has been shown in preclinical studies to play an important regulatory role in lipid homeostasis, inflammation, and cell survival. Human applications may include acute organ injury, chronic metabolic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), and other liver disorders. DURECT’s advanced oral, injectable, and transdermal delivery technologies are designed to enable new indications and enhanced attributes for small-molecule and biologic drugs. One late-stage product candidate in this category is POSIMIR® (SABER®-Bupivacaine), an investigational non-opioid analgesic intended to address key unmet needs in postoperative pain management. Another is REMOXY® ER (oxycodone), based on DURECT’s ORADUR® technology, an investigational extended-release pain reliever that has been out-licensed to Pain Therapeutics, Inc. Opioid medications such as oxycodone expose users to risks of addiction, misuse, and abuse.

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DURECT Corporation to Host Key Opinion Leader Call on Treatment of Primary Sclerosing Cholangitis (PSC)

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DURECT Announces Resubmission of REMOXY® ER New Drug Application by its licensee, Pain Therapeutics

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